Year: 2013 | Month: November | Volume 6 | Issue 4s

In silico Target Deconvolution of Curcumin (Diferuloylmethane) Against Respiratory Syncytial Virus


DOI:Coming soon...

Abstract: <div>In relation to its antiviral properties, curcumin at higher concentrations is found to lower the growth of Respiratory syncytial virus (RSV) in non-tumorigenic human bronchial epithelial cells (BEAS-2B) infected with RSV. However the mechanism of action curcumin in RSV remains unknown. This analysis unlocks the ways to increase the killing of RSV even at lower concentrations of</div><div>curcumin, also preventing apoptosis of the host cells when concentration of curcumin is increased (if a higher concentration is needed). The study has identified the viral proteins RNA polymerase L and Ribonucleoprotein N to be susceptible targets in RSV for binding of curcumin or curcumin bioconjugates to combat the virus</div>



© This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited





Print This Article Email This Article to Your Friend

International Journal of Agriculture Environment & Biotechnology(IJAEB)| In Association with AAEB

13670098 - Visitors since February 20, 2019