Year: 2013 | Month: November | Volume 6 | Issue 4s
In silico Target Deconvolution of Curcumin (Diferuloylmethane) Against Respiratory Syncytial Virus
Abstract: <div>In relation to its antiviral properties, curcumin at higher concentrations is found to lower the growth of Respiratory syncytial virus (RSV) in non-tumorigenic human bronchial epithelial cells (BEAS-2B) infected with RSV. However the mechanism of action curcumin in RSV remains unknown. This analysis unlocks the ways to increase the killing of RSV even at lower concentrations of</div><div>curcumin, also preventing apoptosis of the host cells when concentration of curcumin is increased (if a higher concentration is needed). The study has identified the viral proteins RNA polymerase L and Ribonucleoprotein N to be susceptible targets in RSV for binding of curcumin or curcumin bioconjugates to combat the virus</div>
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