Year: 2013 | Month: November | Volume 6 | Issue 4s
Bioactive Metabolite from Aphyllophorales sp. an Endophytic Fungus Isolated from Breguiera Cylindrica
Abstract: <div>The significance of natural products in the drug discovery and development has been reported extensively. The natural products from mangrove fungi, which are known to be a rich source of bioactive metabolites, are of biotechnological interest. As most of these fungi grow in a unique and extreme habitat, they certainly will play a crucial role in meeting the demand for screening novel bioactive compounds. This is the first report on isolation of basidiomycete endophytic fungus, Aphyllophorales sp. (JQ34006)</div><div>from mangrove plants, Breguiera cylindrica. Among the 44 strains isolated, the ethyl acetate extract of Aphyllophorales sp. exhibited pronounced activity in preliminary antimicrobial screening. The isolated bioactive compound showed an Rf value of 1.5 in Thin layer chromatograpy (TLC) analysis. In high performance liquid chromatography (HPLC) a prominent peak was detected at retention time 2.314 minutes. The FT-IR analysis showed the presence of a benzene ring in the compound represented by characteristic functional group vibrations. The isolate exhibited protease activity. The results indicated that further investigations are still needed to discover other potential of this isolate.</div>
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